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Sony WH-1000XM4 Wireless
Audio-Technica ATH-M50xBT2 Wireless
The Sony WH-1000XM4 Wireless are better than the Audio-Technica ATH-M50xBT2 Wireless for most purposes. They isolate you from much more noise, thanks to their ANC feature, and they're much more comfortable and well-built. On the other hand, the Audio-Technica headphones have a longer continuous battery life. Also, some may prefer their flatter sound profile to the Sony's bass-heavy sound, although both pairs have sound customization features in their apps.
Sony WH-1000XM4 Wireless
Audio-Technica ATH-M50xBT2 Wireless
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Sony WH-1000XM4 Wireless vs Audio-Technica ATH-M50xBT2 Wireless: Main Discussion
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