These are the calibration settings that we used for our review of the 32" Vizio D Series 1080p 2017 (D32f-E1) and should also be good for the 39" version (D39f-E1), the 40" version (D40f-E1), the 43" version (D43f-E1), and the 50" version (D50f-E1) . These settings will work well for everything even gaming, with a few modifications that are listed below.
We started by choosing the 'Calibrated dark' picture mode, as this is the mode which allows the most flexibility over picture settings.
For our calibration process, we turned off the 'Auto Brightness Control', so that the screen luminance would not change depending on the room lighting. We set the 'Backlight' to 51 to reach our goal luminance of 100 cd/m². If you are in a bright room or find our settings too dark, increase 'Backlight' as much as you want and it won't change affect the colors accuracy. We left the 'Brightness to 50, change the 'Contrast' to 49, left the 'Color' to 50, left the 'Tint' to 0.
We selected the 'Normal' 'Color Temperature' since it gave us the closest result toward our calibration goal, but if you find the color to warm you can change it for a cooler color temperature.
We left 'Black Detail' off since it added some image processing and we aim to be as true as possible to the original content.
We also left 'Backlight Control' off since we did not need this for the calibration. Note that the 'Backlight Control' is not a local dimming feature, but a frame dimming feature that dim the screen completely depending on the on-screen content. As such, we think it is better to turn off this feature, as it will change the backlight continuously as it will adapt to the content displayed on the screen.
In the 'Reduce Noise' tab, we left both the 'Reduce Signal Noise' and the 'Reduce Block Noise' off for our calibration, but if you see too many artifacts or too much noise when watching old or low-quality content, enable these noise reduction features. Keep in mind that these soften the picture, so don't turn them on for high-quality content.
We set 'Film Mode' to 'Auto', as when set to auto, 24p movies playing from 24p will be judder free and we did not find any bad side effect of letting this feature set to 'Auto.
On the Vizio D Series 1080p 2017, the most important setting to turn on is the 'Game Low Latency' option. The picture mode you are in does not really change anything to the input lag, so you can be in 'Calibrated dark' and just turn on 'Game Low Latency' and you should have the best input lag available. All HDMI port have the same input lag.
The following are the results of the white balance and colorspace calibration on our unit. They are provided for reference, and should not be copied as the calibration values vary per individual unit even for the same model and same size as the TV we reviewed due to manufacturing tolerances. If you want to try them you will need to enter all values shown, as all of them are active at the same time. If you end up with worse picture quality, simply reset them to the default values.