The Vizio E Series has a very limited set of features, so the calibration of the picture quality is very straightforward.
First, disable the Auto Brightness Control, unless you want the luminosity of the screen to change according to the ambient light of the room. You can control how bright the screen is by using the Backlight setting. We set it to 31 to achieve our target of 100 cd/m2
In Advanced Picture, as usual, we disabled everything. See the Q&A section of our review to see why we disabled the Active LED Zones feature. We also explain there what the Motion Blur Reduction feature does. If you are using low quality content (like cable or streaming), you might want to enable the noise reduction features.
We only do a 2 point grayscale calibration for our reviews, so we only touched the offset and gain of RGB. It was pretty far off by default.